Glynova-M1
Each uncoated bilayered tablet contains :
Glimepiride 1 mg
Metformin HCl 500 mg
(In sustained release form)
Glynova-M2
Each uncoated bilayered tablet contains :
Glimepiride 2 mg
Metformin HCl 500 mg
(In sustained release form)
About the Drug : This is an ideal combination for Type 2 DM as Glimepiride stimulates the insulin release from functioning pancreatic β-cells and inhibits gluconeogenesis at hepatic cells & also increases insulin sensitivity at peripheral target sites whereas Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).
Glynova-MP1
Each uncoated bilayered tablet contains :
Pioglitazone Hydochloride 15 mg
Metformin HCl 500 mg
(In sustained release form)
Glimepiride 1 mg
Glynova-MP2
Each uncoated bilayered tablet contains :
Pioglitazone Hydochloride 15 mg
Metformin HCl 500 mg
(In sustained release form)
Glimepiride 2 mg
About the Drug : The combination of Glimepiride, Pioglitazone and Metformin sustained-release complements each other and provides better glycemic control in the management of Type-2 diabetes and probably in the prevention of its associated macrovascular and microvascular complications.
Glimepiride lowers blood glucose by stimulating the release of insulin from functioning pancreatic beta cells.
Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-GAMMA. It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue and the liver. As a result pioglitazone reduces insulin resistance in the liver and peripheral tissues; increases the expense of insulin-dependent glucose; decreases withdrawal of glucose from the liver; reduces quantity of glucose, insulin and glycated haemoglobin in the bloodstream.
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
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