About the drug: Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures. It has also been found effective for generalized anxiety disorder and is approved for this use in the European Union. It was designed as a more potent successor to gabapentin. Recent studies have shown that pregabalin is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury. In June 2007, pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia.

Like gabapentin, pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. Pregabalin decreases the release of neurotransmitters such as glutamate, noradrenaline. Pregabalin increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity. Glutamic acid decarboxylase (GAD) is the enzyme that converts the excitatory neurotransmitter glutamate into the inhibitory GABA in a single step. For this reason, pregabalin greatly potentiates benzodiazepines & other depressants.

Voltage dependent calcium channels allows the entry of Ca++ ions which are responsible for excitation of neurons, muscular contraction, upregulation of gene expression & release of neurotransmitters & hormones.

Methylcobalamin is a form of vit b12 used in the treatment of peripheral & diabetic neuropathy, depression & fatigue. Methylcobalamin lowers excess glutamate levels (brain damaging properties) & reduces neurotoxicity & depression. Methylcobalamin also facilitates methylation (addition of methyl group for regulation of gene expression & protein function)